Adenomyosis is very similar to endometriosis. In endometriosis, the inside lining of the uterus, the cells that bleed every month, end up in the abdominal cavity on the intestines and bleed there. In adenomyosis, the inside lining of the uterus invades the wall of the uterine muscle and grows there. Both endometriosis and adenomyosis cause pain. The primary symptom of endometriosis and adenomyosis is pain that varies with a cycle. This is because adenomyosis is sensitive to estrogen. Estradiol or xenoestrogens stimulate the adenomyosis to grow. Progesterone, if given with weak xenoestrogens, opposes and balances out these weak xenoestrogens and stops the adenomyosis from growing. In addition, iodine also seems to reduce the patient's sensitivity to xenoestrogens. I also give indole-3-carbinol to my adenomyosis patients with some bioflavonoids. Indole-3-carbinol helps reduce estradiol levels but does not affect xenoestrogen levels. Bioflavonoids seem to potentiate the effect of indole-3-carbinol. I do not give any nattokinase found in Fibrovan. Nattokinase will break down fibrin in blood clots causing increased bleeding.
I was Diagnosed With Adenomyosis
Hi .... could you please cancel my standing order for Progestelle. I find that I no longer need it.
Thank you for a wonderful product that has saved me from a hysterectomy. I was diagnosed with Adenomyosis a few years ago and was told by the gynecologist that a hysterectomy was the only possible remedy. After a few months using the Progestelle (and eliminating many sources of xenoestrogens), my symptoms were 95% gone. I used it for about a year, then quit for a while and my symptoms came back. So, I began using it again and my symptoms went away. At this point, I think I'm far enough along into menopause that I don't need the Progestelle. However, if I find that I need it again, I will most certainly turn to this product again. I have told many people about its effectiveness and have hopefully spared a few women the drastic measure of hysterectomy.
Thanks again for offering this fine product.
Cheryl S - Regina, Saskatchewan
Aug 11, 2009
I Took Progesterone
I took Progesterone for 8 months (Feb2009-Sept2009) for adenomyosis and I was cured. Although I stopped Progestelle I continue to avoid the xenoestrogens (caffeine, parabens, parfum (perfume) etc). I am generally fine, I have some bleeding between periods and mild pain sometimes during periods (most of the time I don't even use painkillers).
The problem is that yesterday I had surgery and I just returned home. My surgeon gave me antibiotics (pills) that contain methylparaben and propylparaben. I also don't know the ingredients of the products they used on me (antiseptics, lotions, etc). For the past few days I had spotting, and yesterday and today even more( it may be due to pre-surgery stress and the products they used on me)
What should I do now? I think it is inevitable to take the antibiotics due to surgery. What do you advise me to do next? I'm afraid that my next period will be a nightmare.
Georgia F - Thessaloniki, Greece
Sept. 15, 2010
Xenoestrogens are chemicals or herbs that mimic the effect of estrogen. Xenoestrogens act like estrogen but are really strange estrogens. They have estrogen-like effects but may cause breast cancer, excess bleeding, the growth of the endometrium in strange places like the abdominal cavity and the uterine wall, premenstrual syndrome, ovarian cysts, and breast cysts. The xenoestrogens in synergy with your own estradiol stimulates the adenomyosis to grow. The xenoestrogens together with your own estradiol "feed" the adenomyosis.
For instance, Margaret Schlumpf and her colleagues at the Institute of pharmacology and toxicology at the University of Zurich in Switzerland found that many of the sunscreen chemicals are xenoestrogens and will trigger developmental problems in rats. She studied six common chemicals using sunscreens, lipsticks, and facial cosmetics. She found five of the six tested chemicals benzophenone-3, 4-MBC, octyl-methoxycinnamate and octyl-dimethyl-PABA acted like estrogen when tested with estrogen sensitive breast cancer cells. Only B-MDM did not show any estrogen activity. They used the same concentrations that were present in sunscreen formulations. 4-MBC combined with olive oil was applied to the rat's skin and caused a doubling rate of the uterine growth before puberty. The three other chemicals caused developmental abnormalities in the rat's progeny.
Not only can certain chemicals mimic estrogen, but these chemicals can also cause conversion of testosterone to estrogen effectively chemically castrating males. For example, Tyrone Hayes of University California Berkeley showed that the commonly used weed killer, atrazine, influenced frogs with minuscule doses of 0.1 ppb (parts per billion). Atrazine can be found in rainwater, snow runoff, and groundwater. Hayes claims that there is virtually no atrazine-free environment. As the concentration of atrazine increases, 20% of frogs exposed during early development produced multiple sexual organs and possessed both male and female attributes. The larynxes of the frogs were smaller and had been feminized. Hayes believes that atrazine was causing the frog cells to produce aromatase that converts the male hormone testosterone to the female hormone estrogen. Atrazine makes male frogs into hermaphrodites. Male frogs exposed atrazine had a decrease in testosterone to levels that were the same as found in female frogs.
Lavender and tea tree oil have been determined to mimic estrogen. Lavender and tea tree oil have been shown to stimulate the activity of estrogen and simultaneously block the action of testosterone. A pediatric endocrinologist, Clifford Bloch M.D., treated young boys for gynecomastia or enlarged breasts. He found that their own hormones were normal by lab tests of their blood. Bloch found that five of the boys had been using shampoo, hair gel, soap that listed lavender oil in its ingredients. Several parents were putting pure lavender oil on their boys' skin. Bloch took away their lavender and tea tree oil products, and their gynecomastia disappeared after several months. He separately took the tea tree oil and lavender oil and tested them with breast cancer cells sensitive to estrogen and breast cancer cells sensitive to testosterone. He found that the tea tree oil and lavender oil stimulated the breast cancer cells sensitive to estrogen to grow. He also found that the tea tree oil and lavender oil stopped the breast cancer cells sensitive to testosterone from growing. He concluded that both tea tree oil and lavender oil possess both estrogenic and anti-androgenic properties. These plant essences are implicated for similar effects on young girls and may be responsible for early puberty and early breast development.
Hormones can also be blocked by natural herbs. Hippocrates back in 460 BC claimed that Queen's Anne's Lace stopped pregnancies. Herbalist, Robin Bennett in 2007, gave Queens Anne's lace to 13 women to prevent pregnancy. She thought that she had a 98% success rate to prevent pregnancy. Extracts of the seeds given to rats, mice, guinea pigs and rabbits showed that the implantation process is interrupted, and the embryo will not implant into the uterus. Progesterone could be blocked by Queens Anne's lace. Progesterone is needed to go into the progesterone receptors to maintain the pregnancy. When Queens Anne's lace blocks the progesterone receptor from progesterone, the pregnancy is prevented.
Xenoestrogens and your own estradiol that your body produces stimulate the adenomyosis to grow.
Nicotine can be taken through skin patches. Nicotine patches can be routinely found at the drugstore to help kick the habit. This demonstrates that stuff on the skin is absorbed directly into the body. Similarly, any chemical and herb put onto the skin are absorbed directly into the body. In fact, anything put on the skin is 10 times in potency to what you eat. This is because anything put on the skin bypasses the liver. Usually, if eaten, the hormone is first passed 90% metabolized by the liver.
So, it is extremely important for the patient to change to shampoos, lotions, laundry detergents, soaps, toothpaste, and cosmetics that are free of xenoestrogens. It is not easy. I looked through 500 shampoos and could only find 3 shampoos that did not have xenoestrogens in them. If you buy any of our products, you will get a list of recommended products free of xenoestrogens. You will also get an Avoidance list of herbs and chemicals that mimic estrogen and that will stimulate adenomyosis to grow.
Medical doctors routinely recommend that endometriosis and adenomyosis patients become pregnant. Because pregnancy slows or stops adenomyosis and endometriosis, doctors advise patients to become pregnant. The two hormones that go high during pregnancy are progesterone and estriol. Progesterone opposes the effect of xenoestrogens. Estriol is a “weak” estrogen that fits into the estrogen receptor. Estriol blocks all the “strong” estrogens from going into the estrogen receptor.
Instead of becoming pregnant, why not just create a fake pregnancy by taking progesterone?
Progesterone can help balance out small amounts of weak xenoestrogens. However, progesterone will make your symptoms worse if you are taking large amounts of potent xenoestrogens. Your body makes three kinds of estrogen. Your body can make estradiol, estriol, and estrone. Your body makes one kind of progesterone. The name of the hormone that your body makes is progesterone.
However, there is a large amount of "pretenders" that pretend to be your estrogen and progesterone. First of all, there are brand-name synthetic estrogens designed to fit into your estrogen receptors. They are unlike your own estrogen because they need to be patented and must be different from your own native estrogen. Therefore, they have estrogen-like effects but may have side effects, like cancer. Similarly, brand name progestins are designed to fit into your progesterone receptor, but again to be patented they must be novel and different from progesterone. Why is patenting so important? The answer is profits and money. Your own estrogen and progesterone cannot be patented since it is found in nature. So you must make the estrogen and progesterone different from what is found in nature so that they can be patented and no one else can use it. Thus, you can charge exorbitant amounts of money and have large profits. You take these large profits and hire expensive sales people to convince medical doctors to prescribe it to their patients. You also need large amounts of money for the expensive TV ads and magazine ads needed to stoke the demand for these synthetic estrogens and progestins. However, these synthetic estrogen and progestins cause cancer according to the Physician’s Desk Reference.
Natural progesterone is routinely used by Fertility Medical Doctors to prevent miscarriage. Natural progesterone does not cause birth defects. Brand-name synthetic progestins cause birth defects according to the Physician’s Desk Reference.
Which would you rather use?
I prefer to give my patients natural progesterone, the same bioidentical progesterone that their bodies make.
1. You take natural progesterone with a few weak xenoestrogens. Progesterone can balance out the estrogen and you feel better.
2. You take natural progesterone with many strong xenoestrogens. Progesterone makes you feel worse and increases your pain. This is really due to you regaining your original sensitivity of your estrogen receptor and is not really due to progesterone itself. Your progesterone receptors wake-up.
3. You take natural progesterone with a few weak xenoestrogens. The progesterone "doesn't work" after two or three months because of the estrogen receptors wake-up.
4. You take natural progesterone with herbs that block progesterone. The progesterone doesn't work at all. You think something is wrong with your bottle. Some common herbs that block the progesterone are aloe and mint.
5. You completely eliminate xenoestrogens from your life. You become normal. No progesterone is needed.
Chronic xenoestrogen exposure leads to reduced sensitivity to estrogen. The body shuts down the estrogen receptors to protect itself because of the constant xenoestrogen stimulation. Chronic xenoestrogen exposure means you are not as sensitive as other people to xenoestrogens. When you take progesterone, the estrogen receptors wake-up. You regain your normal sensitivity to estrogen. Now, it seems that you are getting more estrogen when you are really not. Thus, it seems that progesterone is making you worse. But that is not really what is happening. What is really happening is you're sensitivity to estrogen is changing set you are more sensitive to estrogen.
This phenomenon is called down regulation. It happens frequently to our hearing. For instance, if you go to a loud rock concert, initially it sounds really loud. However, after half an hour it is not so loud anymore. This is because your ears down regulate. When your ears down-regulate you become less sensitive to the noise. Now, you take progesterone. Your ears up-regulate back up to its original sensitivity. Now, the rock concert seems loud again. You blame progesterone. However, that is not really what is happening. Your ears have become more sensitive to the noise. Your ears have regained their original sensitivity to sound.
Similarly, progesterone wakes up your "sleepy" estrogen receptors. The estrogen receptors were "sleepy" because of the chronic xenoestrogens exposure.
What is the solution? The solution is to stop all the noise, and then take progesterone. So, I recommend that all my patients eliminate all xenoestrogens from their environment for one to three months and then take progesterone. This is extremely critical for the more seriously ill patients that have adenomyosis or endometriosis. Usually, if they take progesterone straightaway all their symptoms will get worse. It is not from the progesterone. It is from their heightened sensitivity (regain their original sensitivity) of their estrogen receptors.
So the culprit of their real problem is xenoestrogens, not progesterone.
Iodine seems to reduce your sensitivity to xenoestrogens. I had a lady in the UK as well add a small fibroid the size of golf ball. She went on our program of avoiding xenoestrogens and being on progesterone. After about five months, the size of the fibroid had not changed. She began to read about the benefits of taking iodine for female diseases. She found a small bottle of iodine in the grocery store on clearance for £.50. She began to take the iodine. Your fibroid disappeared in three weeks.
I had a second woman in the UK that had endometriosis pain that she ranked 10 out of 10 (where 10 is the pain of childbirth). After five months avoiding xenoestrogens and being on progesterone, her pain was three out of 10. She was elated by this change. I told her about the iodine and she began to take it. After three weeks, her pain was zero out of 10.
Iodine works to reduce your xenoestrogen sensitivity by converting strong estradiol to weak estriol. Dr. Jonathan Wright, MD has never seen this written up but has observed in several hundred patients that iodine given to patients reduces estradiol and estrone, and increases estriol. Estradiol is strong. Estradiol stimulates adenomyosis to grow. Estriol is weak. Estriol goes up during pregnancy. Pregnancy is known to stop adenomyosis to grow. Taking iodine increases estriol at the expense of estradiol.
I recommend taking two types of iodine. Either you may take Lugol's iodine, or you may Iodoral. Lugol's iodine has been around since the 1850s. Both consist of atomic iodine or I2, and iodide the iodine ion, I-. Lugol's iodine is cheap, but it stains the clothes if put on the skin, and can stain the tongue. Lugol's iodine may also cause stomach upset. Iodoral is expensive. However, Iodoral is convenient and painless to take. Is important to take both contain iodine, I2, and iodide, I- because some tissues take up iodine and some tissues take up iodide. Your body needs both kinds of iodine.
The iodine in table salt is not enough to maintain optimal functioning of the body. The normal Japanese citizen takes about 10 mg of iodine per day. During the late 1800s, there was a goiter belt in the Midwest in the Great Lakes region. This was because of an iodine deficiency. Table salt was mandated to be iodized. The goiters disappeared. This was a great triumph for public health. The reason why the goiters occurred in the Midwest around the Great Lakes region was because there was a severe deficiency in the soil of iodine. The reason why is that the glaciers when they scooped out the Great Lakes also scooped out the soil that contains iodine. Iodine was in ocean water that soaked into the soil around the Great Lakes eons ago. That soil was scooped out by the glaciers. Therefore, the area around the Great Lakes region is deficient in iodine.
Because of this deficiency in iodine, goiters appeared. However, the iodine in table salt is just enough to stave off goiters. It is not enough for optimal functioning of the human body. Abraham M.D. recommends 10 mg of iodine per day. This is the same dose of iodine a Japanese citizen gets.
The problem with taking iodine is that it will force out other toxic elements of out of the body such as bromine. Bromine is in the same column of the periodic table as iodine and relatively the same size as iodine. So bromine and iodine compete for the same chemical sites. Thyroid hormone, T3, and T4, has three iodine atoms and four iodine atoms respectively. It may be possible that bromine substitutes for iodine in your thyroid hormone rendering the thyroid hormone useless. In other words, your thyroid hormone is polluted by bromine and does not work anymore. However, the thyroid hormone level would appear to be normal in a blood lab test even though it is a polluted defective thyroid hormone. The polluted defective thyroid hormone with bromine would not work correctly in your body. This means that your effective thyroid hormone would be lower and you would be hypothyroid.
In other words, bromine in corrupting your thyroid hormone and makes you become hypothyroid. You are hypothyroid because you are poisoned with bromine even though your thyroid hormones are normal.
The second problem with hypothyroid is that the thyroid receptor becomes "sleepy" as well with xenoestrogen exposure. Estrogen in synergy with xenoestrogens tell the body to build up fat for the pregnancy. How does it tell the body to build up fat the pregnancy? Xenoestrogens and estrogen together lower your metabolism by reducing the sensitivity of your thyroid receptor. You become less sensitive to thyroid hormone because xenoestrogens are telling your body to become fat. Xenoestrogens tell your body to be fat.
Removing xenoestrogens many times causes loss of fat. The fat can sometimes release xenoestrogens stored in the fat. These released xenoestrogens can make your adenomyosis worse.
So, when you take iodine, iodine forces out toxic bromine. Then you are dealing with bromine toxicity. When I took iodine I had heart palpitations and vivid dreams. The heart palpitations and vivid dreams lasted for about two weeks and then the bromine toxicity stopped. Now I can take 50 mg of iodine per day and have no adverse effects at all. Bromine toxicity can lead to symptoms such as a metallic taste in the mouth, frontal sinus pressure, and pain, increased salivation, eyelid twitching and twitching tingling in the hands and feet, depression, anxiety, emotionality, mouth and tongue sores, acne with a rash, skin cuts, hair loss, brain fog, legs and hip, a metallic taste, sinus acne, headache, sedation, lethargy, odd falling sensation, body order, strange odor, dry mouth, frequent urination, diarrhea, constipation, vision changes, irritability, and transient breast tenderness. The most worrisome side effect which occurs in one out of 400 people is a sore thyroid. The sore thyroid indicates that the thyroid cells may be breaking up. These breaking up thyroid cells lead to thyroid insides of the cells being spread all over the body and an autoimmune reaction being mounted. This may result in a Hashimoto's thyroiditis. In this case, stop the iodine immediately. It is important to realize that this is bromine toxicity. These side effects are not from iodine. Do not blame the iodine. The side effects are from bromine.
It is also important to ramp up the iodine extremely slowly because you do not want to detox very quickly and become very sick. I usually start with 3 mg/day or less and ramp up 5 mg per day every week. If you are undergoing a detox reaction from bromine, stop the iodine immediately, or go back down on the dose of iodine.
Where is this bromine coming from? One of the main sources of bromine is brominated vegetable oil in soft drinks and sports drinks. As of 2014, PepsiCo has taken out brominated vegetable oil from some of its products. Coca-Cola is talking about following suit is well. Bromine is also found in commercial bakery products, flour, sleep aids, asthma inhalers, and some fungicides. Obviously, if you keep taking bromine, you cannot detox from bromine.
I also recommend taking indole-3-carbinol to reduce your own estradiol. Indole-3-carbinol is found naturally in Brussels sprouts, broccoli, and cabbage. Indole-3-carbinol gives your body the raw materials to metabolize estradiol more quickly. Indole-3-carbinol does not affect xenoestrogens at all. You may take 400 to 600 mg per day of indole-3-carbinol per day. Usually, this helps relieve the pain and symptoms of endometriosis and adenomyosis. This is because the synergistic effect of estradiol and xenoestrogens is feeding your adenomyosis to grow and if you cut back on your estrogen estradiol by taking indole-3-carbinol this reduces the "food" for the adenomyosis to grow. I also give lemon bioflavonoids with indole -3-carbinol. Bioflavonoids are like a fancy vitamin C. Bioflavonoids seem to potentiate the effect of indole -3-carbinol.
The most important thing about taking indole-3-carbinol is that it cannot contain rosemary. Rosemary is extremely estrogenic and will make your adenomyosis worse, much worse. Rosemary is put into the indole-3-carbinol to prevent the indole-3-carbinol from the degrading. Rosemary is used as an antioxidant. Indole-3-carbinol will degrade at 5% after six months at room temperature without the rosemary. So, I sell indole-3-carbinol without rosemary, and it must be refrigerated.
DIM is also used to reduce estradiol. DIM is supposed to have less nausea and side effects than indole -3-carbinol. Indole-3-carbinol goes into the stomach and one of the 20 metabolites produced is dim. However, I've had no results using DIM in my fibroid patients. I have asked many of my colleagues in the alternative medicine health field, and they say that they have had no luck with DIM and fibroids as well. However, some of my endometriosis patients say that they like to use dim, and they think it helps their disease.
Nattokinase can increase bleeding by destroying the fibrin in the blood clot. So, my adenomyosis patients that have taken nattokinase have suffered from excessive bleeding. So, I do not recommend nattokinase for my adenomyosis patients. Nattokinase is contraindicated in adenomyosis because of the excessive bleeding.
Xenoestrogens cause a magnesium deficiency. A magnesium deficiency is most easily diagnosed by a chocolate craving right before your period. Chocolate is high in magnesium. So a chocolate craving manifests when you have a magnesium deficiency. After several months, the magnesium deficiency/chocolate craving disappears if you have been really careful to avoid all xenoestrogens and taken enough magnesium supplements. After xenoestrogens are removed from your environment for several months, you will NOT need magnesium supplements.
Chocolate contains xenoestrogens. Cocoa powder can have as high as an 11% concentration by weight of theobromide. Theobromide is a known xenoestrogen. So chocolate will make the magnesium deficiency worse at the same time as adding magnesium.
Magnesium deficiency makes muscles cramp up and tense. The uterus is simply a spherical muscle. A magnesium deficiency leads to uterine cramping. Leg muscles can also cramp up due to a magnesium deficiency leading to a “Charlie Horse”. Neck muscles can tense up due to a magnesium deficiency. The arterioles in your arm are surrounded by a muscular sheath. A magnesium deficiency can cause constriction of the arterioles leading to your hands leading to cold hands and feet. Cold hands or feet is a symptom of magnesium deficiency. Putting your hand under cold water can result in an arteriole spasm with severe constriction of the arterioles. This may lead to something that looks like a Reynaud’s syndrome. The intestine is merely a tubular muscle. A Magnesium deficiency may lead to constipation.
Magnesium oxide has an absorption rate of 4%. A chelated magnesium may have an absorption rate of 40%. I recommend magnesium glycinate 400-600 mg/day. Too much magnesium may lead to diarrhea and loose stools. If you do have loose stools merely cut back on the magnesium.
Xenoestrogens cause a Vitamin B deficiency. A Vitamin B deficiency results in a nerve disease or neuropathy. This neuropathy may manifest as a creepy crawling feeling or burning sensation on the legs that is worse at night. This neuropathy frequently keeps women from sleeping and can be simply tormenting. This is labeled as Restless Leg Syndrome.
The answer is quite simple. Just take a Vitamin B-100 in the morning. After several months, the neuropathy should improve with a regular dose a Vitamin B-100 unless there is a malabsorption problem in the gut. Vitamin B-100 may cause insomnia and vivid dreams if taken just before bedtime. So I usually recommend taking Vitamin B-100 in the morning to avoid insomnia and vivid dreams. Vitamin B is water soluble. So, any excess Vitamin B washes out with the urine. The only danger is Vitamin B6. Rarely, in amounts of 200 mg/day or more of Vitamin B6, a permanent neuropathy could result. However, a Vitamin B-100 usually only contains 50 mg of Vitamin B6.
1. Avoid xenoestrogens because xenoestrogens cause adenomyosis. Buy any product from us and get a free No-No list and free list of recommended products.
2. Take Natural Progesterone because Natural Progesterone balances out mild xenoestrogen exposure. Mimic pregnancy by taking progesterone. Pregnancy stops adenomyosis.
3. Take iodine in the form of Lugols iodine or Iodoral. Iodine converts strong estradiol to weak estriol. Estriol is the estrogen of pregnancy. Pregnancy stops adenomyosis.
4. Take Indole-3-carbinol. Indole-3-carbinol reduces your own estradiol.
5. Take Magnesium Glycinate 400-600 mg/day because xenoestrogens cause a magnesium deficiency. Magnesium deficiency leads to muscle tensing and cramping.
6. Take a Vitamin B-100 in the morning because xenoestrogens cause a Vitamin B deficiency. A vitamin B deficiency causes a nerve disease (neuropathy). Vitamin B causes vivid dreams and perhaps insomnia. Taking the Vitamin B in the morning minimizes vivid dreams.
1. Schlumpf, Margaret; Beata Cotton, Marianne Conscience, Vreni Haller, Beate Steinman, Walter Lichtensteiger. " In vitro and in vivo estrogenicity of UV screens." Environmental Health Perspectives volume 109 (March 2001) pages 239-244.