Estradiol stimulates fibroids to grow. Indole-3-Carbinol helps the body get rid of estradiol faster. Endovan contains Nattokinase. Nattokinase dissolves fibrin. Most BUT NOT ALL uterine fibroids are composed mostly of fibrin. The minority of fibroids are composed of mostly smooth muscle. Nattokinse does NOT work for the less common smooth muscle fibroids. Progesterone opposes the effect of estradiol IF smaller than a grapefruit.

Endovan contains LONG LIFE (compared to others - last 8-12 hours in the body vs. 2-3 hours in the body) Nattokinase with maltodextrin. Nattokinase dissolves blood clots and adhesions in the abdomen. Nattokinase dissolves fibrin. Fibrin is the "fiber" in a blood clot. Most but not all uterine fibroids (myomas) contain mostly fibrin. Discovered at the University of Chicago Medical Center by Dr. Sumi, Nattokinase safely dissolves the blood clots. Nattokinase dissolves adhesions. Vitamin K2 is taken out of the Nattokinase in Fibrovan. Vitamin K is used by the body to clot blood. Thus, Nattokinase in Endovan is NOT contraindicated with Coumadin theoretically.

CAUTION: Some Adenomyosis patients that have had excessive vaginal bleeding experienced more excessive bleeding with ENDOVAN. IF you have Adenomyosis, DO NOT TAKE ENDOVAN!!!

Nattokinase

The miracle enzyme discovered at the University of Chicago Medical School that safely and quickly dissolves unhealthy clots and fibrin deposits in fibroids and endometriosis.

Nattokinase is a potent fibrinolytic (clot-dissolving enzyme) extracted from a traditional Japanese cheese called Natto. Natto has been used as a food and a medical remedy for heart and vascular disease in Japanese culture for over 1000 years. Exciting research since 1980 has shown that Nattokinase helps our bodies dissolve and prevent unhealthy blood coagulation. It is now proven to have 4 times the clot dissolving power of plasmin! Plasmin is what our body produces to dissolve harmful blood clots or excess fibrin that can lead to many serious and fatal diseases including stroke and heart attack.

The Nattokinase that is used in this product does NOT contain phytoestrogens from soy.
How is Nattokinase made?
Natto cheese is made by adding beneficial bacteria Bacillus subtilis to boiled soybeans. When these bacteria act on the soybeans the enzyme Nattokinase is produced. Although other soy foods contain enzymes only the Natto preparation contains this special enzyme Nattokinase.

How was Nattokinase discovered?
In 1980 Japanese researcher Dr. Hiroyuki Sumi was searching for a natural thrombolytic (clot dissolving ) agent. After testing over 173 natural foods at the University of Chicago Medical School Dr. Sumi found what he was looking for. When he placed natto on artificial blood clots in his laboratory at body temperature the blood clots were dissolved within 18 hours! Dr. Sumi named his new discovery "nattokinase" which means "enzyme in natto." Excitedly he stated that nattokinase demonstrated "a potency matched by no other enzyme."

How does Nattokinase work?
Nattokinase enhances our body's ability to fight blood clots. Other blood thinners are exensive, short acting and have serious side-effects. Nattokinase has a prolonged effect without many side-effects associated with Coumadin and Warfarin. It is an enzyme that digests fibrin directly and indirectly. Indirectly, it activates pro-urokinase and tissue plasminogen activator (t-PA), supporting the fibrolytic activity of plasmin. These combined actions promote healthy platelet function, circulation and blood flow. About 10% of its affect is based on direct fibrinolytic activity whereas 90% is based on its ability to upregulate the plasminogen system.

Nattokinase:

supports normal blood pressure
prevents unhealthy blood clots from forming
dissolves existing blood clots
dissolves excess fibrin
increases the body's production of plasmin as well as other clot-dissolving agents.
What research has been done on Nattokinase?
Nattokinase has been the subject of 17 studies with new ones ongoing. Starting in 1990 Dr. Sumi's research team published a series of studies demonstrating the fibrinolytic effect of Nattokinase. Here are some highlights:

Researchers from JCR Pharmaceuticals, Oklahoma State University, and Miyazaki Medical College tested Nattokinase on healthy human subjects who were given Natto after creating artificial blood clots. Amazingly the time it took to dissolve the clots was cut in half. Also this clot-dissolving ability lasted up to 8 hours!
In 4 out of 5 volunteers with high blood pressure who were given Nattokinase for 4 days the average blood pressure dropped at least 10%.
Green Tea Extract

The most potent anti-oxidant known today. It is found in Green Tea leaves and grape seeds. New research shows it has many benefits in cancer prevention,weight loss, immune system enhancement, cholesterol lowering, cardiovascular health, and protecting our bodies from free radical damage.

EGCG (Epigallocatechin gallate) is the most potent antioxidant found in green tea leaves and grape seeds. In developing the NATTO ULTRA formula careful consideration was given to include the most useful as well as safe antioxidant science currently offers.
New research shows Green Tea Extract may:

Lower LDL Cholesterolin low fat diet subjects
Stimulate our immune system
Improve cancer prognosis
May enhance blood flow
Enhance weight loss
Improve dental health
Skin care, including protection against skin cancer
Resist and fight infectious disease.
How does it work?
As a potent antioxidant EGCG protects cells and their DNA by counteracting the effect of free radicals, toxic compounds in our bodies that play a role in many diseases.

References and further reading:

Archives of Internal medicine, June 2003 (Lowers cholesterol) LDL in low-fat diet.
Maryam R.Sartipourr et al. Green Tea inhibits Vascular Endothelial Growth FActor (VEGF) Induction in Human Breast Cancer Cells. The American Society for Nutritional Sciences. Nutr 132:2307_2311,2002.
Br J Cancer 2002; 86 10:1645-51.
Biol Trqce Elem Res 2002;86(2):177-91.
Cancer Epidemiol Biomarkers Prev 2002; 11(8);712-8.
Carcinogenesis 2002:1307-13.
Cancer Lett 2002;177(1):49-56.
Int.Journal of Oncology 2002 Jun;20(6):1233-9.
Food Chem Toxicol 2002;40:1145-54.
Pancreas 2002;25:45-8.
Biochem Pharmacol 2002;63:2145-9.
Environ Mol Mutagen 2002;39(2-3):271-8.
J Nutr 2002; 132(8):2307-11.
Prostaglandins Leuot Essent Fatty Acids 2002;66:519-24.
Does Endovan have any contraindications or side effects?

Endovan was designed with ingredients whose safety has been well studied since 1980. However, due to potential synergistic effects, concurrent use with anticoagulant and blood pressure medications should be closely supervised by a health professional. It is contraindicated for individuals with a history of bleeding tendency or with conditions associated with bleeding.

Nattokinase works to up-regulate the bodys natural plasminogen system, which regulates itself. Because of this, nattokinse does not circumnavigate the bodys own checks and balances. Studies examining the effect of nattokinase administration on tissue plasminogen activator(tPa), euglobulin lysis time, fibrin degradation products and blood fluidity tests have not revealed contraindications on these parameters, though all individuals are different. Ralph Holsworth, DO has occasionally measured euglobulin lysis time (ELT). ELT indicates the activity of plasmin. He did not observe indications of excessive activity of the plasminogen system in the individuals he tested. Furthermore, an acute toxicity study demonstrated that nattokinase was safe at levels hundreds of times greater than the recommended human dose.

What about individuals taking antihypertensive medications, fibrinolytic agents or aspirin. Are these contraindicated with nattokinase?

Nattokinase is not contraindicated with these, although close medical supervision is always suggested. Follow up blood pressure monitoring with their health professional is important, especially if they are also taking medications for hypertension (due to a potential synergistic effect).

A number of supplements also influence platelet function and fibrinolytic activity, including fish oil, coq10, ginger, garlic, bromelain, pycnogenol, ginkgo, vitamin E, and vitamin C. Are these safe to combine with nattokinase?

Again, nattokinases mechanism of action is very different and it is safe to combine it with these types of products. It is advised, however, that other enzymes not be taken while supplementing with nattokinase. This preserves its full potential by not forcing it to compete for absorption.

Follow this link for a very nice review paper on how Nattokinase can help with Cardiovascular diseases like stroke and heart attacks.

Guarantee

Endovan is 100% unconditionally guaranteed. If for any reason you are not completely satisfied with Endovan, simply return your order within 60 days for a full and prompt refund. Refunds limited to the amount of your most recent purchase.