• From 1999-2016 over 30,000 customers
• 83% of Women Taking Transdermal Progesterone Alone Reduced Hot Flushes and Hot Flashes [1].
• Medical Doctor Formulated
• No Preservatives, No Herbs, No Fragrance, No GMO, No Corn, No Gluten, All Natural
• List of Chemicals or Herbs to avoid that are Estrogen Mimics (xenoestrogens) that will interact with progesterone negatively
• List of Safe Products to use that do NOT contain xenoestrogens

A study by Leonetti in 1999, took 105 women that were in within 5 years of menopause.  They were divided into progesterone treatment groups and placebo groups. 43 women were treated with 20 mg of transdermal progesterone.  47 women were treated with a placebo.  30 of the transdermal progesterone group and 26 of the placebo group complained of hot flushes or hot flashes. 25 of the 30 women, 83%, complaining of hot flashes improved with 20 mg/day of transdermal progesterone. The women recorded their vasomotor symptoms in a diary.  5 of the 26 women, 19%, complaining of hot flashes improved with the placebo cream [1]. 

Another study used 80 women in a double blind randomized placebo controlled experiment to evaluate topical transdermal progesterone usage in women with menopausal hot flashes [2].  Unfortunately, the progesterone cream that they used contained several other ingredients known to have hormonal effects or endocrine disrupting effects as well.  The cream that they used contained aloe vera, lanolin, black cohosh, mexican wild yam extract, and burdock root as well as many other ingredients.  Aloe vera is used in some cultures to create miscarriage.  I do not agree with this morally.  In some cultures, if you do not want your pregnancy, and you drink enough aloe during the first trimester this will create a miscarriage.  Anecdotally, I have found that women drinking large amounts of aloe find that progesterone cream has no effect.  The dosage of aloe to create a miscarriage is extremely important according to Bullough.  What dosage of aloe was used in the progesterone cream that they used?  They did not say.  Aloe active comopnents can vary with batches, when they are harvested, and what part of the plant is used.  Did they measure the active component of aloe that blocks progesterone?  Sadly no.  Aloe vera put topically on the skin is absorbed into the body, and may also block progesterone at the receptor level [3].  Lanolin typically is contaminated with pesticide, and many pesticides are known endocrine disruptors or hormone disruptors.

This study with 80 women did not find any change in vasomotor symptoms, mood chararacteristics, or sexual feelings. There was no change in blood lipid levels or bone metabolic markers despite a slight elevation of blood progesterone levels.  They concluded that transdermal progesterone was ineffective for menopausal symptoms. [2]

First, neither study controled all the other topicals on the patients bodies' such as shampoo, lotions, cosmetics, laundry detergents, and tooth paste.  All these topicals contain chemicals or herbs that will interact with progesterone.  Aloe in the progesterone cream, in the second study, will block progesterone making progesterone ineffective.

Are the patients using other products with aloe in them?  They did not look for it.  Most things put on the skin are absorbed into the body.

Secondly, transdermal progesterone is never found in the blood.  Transdermal progesterone can only be evaluated through saliva hormone tests.

Progesterone Oil purer than Progesterone Cream. First time purchasers of any of our products receive a Booklet on how to use Natural Progesterone Cream. Some chemicals and herbs look like estrogen to the body.  These chemicals and herbs that mimic estrogen are collectively known as xenoestrogens or endocrine disruptors. Xenoestrogens found in toiletries, cosmetics, and  house hold products are synergistically acting with your own estradiol and making Estrogen Dominant. Xenoestrogens are not good for you.  Xenoestrogens should be avoided.  Xenoestrogens combines with progesterone cream and can make you sicker.

Forty percent (40%) of patients using progesterone cream have transitory bad side effects. Stopping the progesterone cream allows bad side effects to cease.  It may take abut 1-3 months for the xenoestrogens to wash out of the body since the xenoestrogens are fat soluble. These bad side effects are from taking both progesterone cream and xenoestrogens simultaneously. Estrogen mimicking chemicals and herbs create are creating your disease.  Many women that completely eliminate xenoestrogens become well even without progesterone.  Anything on the skin is ten times (10X) in potency than what is taken orally.  So, most of the xenoestrogens that are causing the problem are likely coming into the body through the skin.  Anything on the skin gets absorbed directly into the body and goes around liver.

Chemical estrogens, endocrine disruptors, xenoestrogens, phytoestrogens, or environmental estrogens are the cause of most women's female diseases. If these women remove xenoestrogens from their environment, then the bad side effects from progesterone will stop. Many customers, after cutting out these chemicals and herbs, find that they do not need progesterone after several months. The goal is just to be healthy without taking anything at all.  From 1999 until 2015, we have compiled a list xenoestrogens to avoid.  I have also compiled a list of safe products to use as well.  If the patients only use products from that "safe"list, then many times the disease disappears.

A cosmetic cream is oil mixed with water. An emulsifier allows oil and water to stay together. A thickener is included to the oil/water emulsification. A preservatve is added to the cosmetic cream to prevent bacterial growth in the cream.  Unfortunately, many times the preservative added is a xenoestrogen.  When the topical cream is applied to the skin, the water evaporates, and only the oil is left on the skin. The progesterone is an "oily" compound.  The progesterone dissolves in the oil.  Progesterone does not dissolve in water. Many of these chemicals such as the emulsifier have an unpleasant smell.  Thus, a fragrance is added to cover the smell of the emulsifier.  The fragrances natural or synthetic are many times estrogen mimics and will act in synergy with estrogen creating Estrogen Dominance and make your disease worse.

Progestelle is only fractionated coconut oil and natural bioidentical progesterone.  I believe less is more. In some cases, 1 out of 400 people, there is an allergy to coconut oil. In these allergy cases, we have progesterone dissolved in olive oil or grapeseed oil.  However, it is diluted by twice as much.  The most important thing to remember is that it is NOT about the progesterone.  It is about everything else that you are putting on the skin.

The Progestelle is in a glass bottle for 2 reasons:  1. Some plastics outgas into the product with byproducts that can be xenoestrogens.  BPA comes to mind.  2. Plastic can also let oxygen through.   The oxygen can oxidize and destroy the progesteorne.  Glass does not allow oxygen to pass through.  Oil also stops oxygen.  In contrast the water in creams contains oxygen and usually oxidizes the progesterone and destroys the progesterone over a period of a year.  Our product does not contain water and does not contain oxygen and can last longer than comparable cream in terms of shelf life.

Safety Information

Progesterone cream if used by mistake during pregnancy, progesterone should not be stopped.  Progesterone use during pregnancy should be overseen by a medical doctor.  Suddenly stopping the progesterone cream while pregnant, can result in a miscarriage.  Immediately, see a medical doctor skilled in the use of progesterone when using progesterone during pregnancy.  Instead the progesterone cream should be tapered off slowly at 16 to 20 weeks.  However, in about 10% of these patients, they need to use progesterone for the entire pregnancy.  These patients may have developed antibodies against progesterone.

Scientific studies demonstrate that for some but not all patients with premature delivery, progesterone can change the premature delivery to a full term pregnancy. 

Progesterone taken before ovulatoin may stop ovulation.  The ovaries look at the progesterone level before ovulation and think that the woman is pregnant and will not ovulate.  However, progesterone cream should not be used as contraception.  Progesterone taken after ovulation may enhance fertility.

Women that are pregnant and deliver multiple times are exposed to high levels of natural progesterone from their pregnancy. These women have a smaller chance of breast cancer and endometrial cancer.  It is thought that natural progesterone helps to prevent cancer.

Progesterone can cause a temporary worsening of Estrogen Dominance symptoms if taken simultaneously with strong xenoestrogens.  Strong xenoestrogens cause Estrogen Dominance.  The body tries to protect itself from Estrogen Dominance by becoming less sensitive to estrogen.  The body tries to shut down estrogen sensitivity.  This is known as "Down Regulation" in biology.  It is like going to a noisy rock concert.  After about 1/2 hour, you become less sensitive to the noise.  This is "Down Regulation".

Progesterone wakes up the estrogen receptors back to normal and then you become worse.

The solution is to eliminate xenoestrogens for 1-3 months, then take progesterone.  Then, when you take progesterone and the estrogen receptors wake up there is no xenoestrogens to cause Estrogen Dominance.  It takes 1-3 months for xenoestrogens to wash out of the body.

Estrogen Dominance is fat on the belly and hips, thinning hair, bloating and breast tenderness, headaches, water retention, and magnesium deficiency.

Progesterone use may decrease your need for thyroid hormone because the thyroid receptors will wake up.  Estrogen Dominance decreases thyroid receptor sensitivity.  Estrogen Dominance causes hypothyroid without lowering thyroid hormones.

Indications

Female conditions: Ovarian Cysts, Restless Leg Syndrome, Menstrual Migraines, Weight Loss, Hair Loss, Menopause, Menstrual Cramps, Dysmenorrhea, Menorrhagia, Excessive Menstrual Bleeding, Endometriosis, PMS, Adenomyosis, Breast Cysts

Ingredients
2 ingredients Only: Coconut oil, Natural Bioidentical Progesterone USP Pharmaceutical Grade 800 mg/oz. 1 oz per bottle. Each bottle contains 40 dropperfuls. Each dropperful with 2 inches of oil contains 20 mg of progesterone.

Directions
Put on the skin twice a day. Change areas so that the subcutaneous fat does not saturate. Progestelle is Double the Strength when compared to most progesterone creams. Use 1-3 dropperfuls (20-60 mg) per day. A dropperful with 2 inches of Progestelle oil has 20 mg of progesterone.  Use Natural Progesterone from days 14-26 where day 1 is the first day of your period. You may use progesterone anytime you do not have a period, if you don't want to conceive immediately.  Each one ounce bottle contains 40 dropperfuls.  Each dropperful has 20 mg of progesterone. This is double the concentration of most progesterone creams on the market. This means less oil.

Notes:

1. Leonetti HB, Longo S, Anasti JM. Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone loss. Obstet Gynecol 1999; 94: 225-228.

2. Wren BG, Champion SM, Willets K, et al. Transdermal progesterone and its effect on vasomotor symptoms, blood lipid levels, bone metabolic markers, mood, and quality of life for postmenopausal women.Menopause 2003; 10: 13-18.

3. Bullough, Vern, Encyclopedia of Birth Control, ABC Clio, Santa Barbara, California, 2001, 126.