Indole-3-carbinol (I3C) Pure Encapsulations contains indole-3-carbinol.   Indole-3-carbinol is found naturally in cruciferous vegetables.  Cruciferous vegetables include cabbage, bok choy, broccoli, brussels sprouts,  or cauliflower. Phase I and phase II liver detoxification is helped by indole-3-carbinol. Indole-3-carbinol helps healthy estrogen metabolism. Indole-3-carbinol helps healthy estrogen metabolism in human lab tests. Indole-3-carbinol creates a good ratio of weak estrogens (2-hydroxyestrone metabolites or 2-OHE) to strong estrogens (16 alpha-hydroxyestrone metabolites or 16 alpha-OHE).  Indole-3-carbinol creates more weak estrogens. One human trial showed indole-3-carbinol helped cervical cell health.  Healthy estrogen balance from indole-3-carbinol helped normalize the cervical cell health. Use 400-1000 mg/day. Ramp up the dose slowly.  If the indole-3-carbinol creates nausea or vomiting cut back on the dose. Indole-3-carbinol may cause trasitory hot flashes.  Inddole-3-carbinol is contraindicated in lactating or pregnant women. Pure Encapsulation does NOT have rosemary.  Rosemary mimics estrogen and may make some Estrogen Dominant diseases worse. New Size 400 mg and 60 caps.