Natural Progesterone Reverses Traumatic Brain Injury - Case Study
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One of my young patients was playing basketball. An opposing team member ran into her, and she had a brain concussion. I found out about the accident several months later. She was still having the effects of the brain injury. Whenever she would read she would get a headache. For her, this was very upsetting because she loved reading.
I knew that natural progesterone was being used for concussions hours after the injury, but wondered whether or not it would have any effect on a concussion that was several months old.
Progesterone has many hormonal effects that "calm down" the inflammation of the nervous system.
I thought that there was nothing to lose, since Natural Progesterone is relatively safe.
So, she took Natural Progesterone for about a month, and the headaches went away. However, I am not sure whether or not the Topical Natural Progesterone made a difference or not.
Progesterone is being used for Traumatic Brain Injury.
So, Mark came in with a very severe traumatic brain injury-- what we call a Glasgow Coma Scale of 4-- somewhere around 4 to 6--when he came in. There was limited expectation that he would recover fully. Most people who come in with that level of impairment either die or have a devastating long-term outcome. Mark was one of our hero stories. He was in the first trial--the safety trial in 2001. You know, it's quite a remarkable story. His parents came basically to the ER to say goodbye, and Mark was enrolled in the trial. At the time, we didn't know whether he got the study drug or placebo because it was a blinded trial. At the end of the trial, we were able to break the blinding and realize that this gentleman was in the treatment group. Why that's remarkable is because he had an unbelievable recovery. Mark basically is back to his normal self. He's essentially a weight-lifter, athletic individual. We're very proud of him and very happy that he's done so well. Now, we can't for sure say that progesterone was the reason why he recovered so well, but it certainly gives us hope. Traumatic brain injury is tricky. There are a number of patients who come in who are severely injured who actually do quite well. The reason behind that is not really well known. There are individual genetic characteristics and the type of injury they had and things like that that play a role. But the fact that he was so severely injured and did well and was in the treatment group gives us a lot of hope. We're studying progesterone for use in severe and moderate TBI which we think is very important because it will help show functional improvement as opposed to just improving death. There's no reason to think that it wouldn't work for mild, but we haven't studied that.